The C-terminal domain of the MERS coronavirus M protein contains a trans-Golgi network localization signal
Identifieur interne : 000353 ( Main/Exploration ); précédent : 000352; suivant : 000354The C-terminal domain of the MERS coronavirus M protein contains a trans-Golgi network localization signal
Auteurs : Anabelle Perrier [France] ; Ariane Bonnin [France] ; Lowiese Desmarets [France] ; Adeline Danneels [France] ; Anne Goffard [France] ; Yves Rouillé [France] ; Jean Dubuisson [France] ; Sandrine Belouzard [France]Source :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2019.
English descriptors
- mix :
Abstract
Coronavirus M proteins represent the major protein component of the viral
envelope. They play an essential role during viral assembly by interacting with
all of the other structural proteins. Coronaviruses bud into the endoplasmic
reticulum (ER)–Golgi intermediate compartment (ERGIC), but the mechanisms
by which M proteins are transported from their site of synthesis, the ER, to the
budding site remain poorly understood. Here, we investigated the intracellular
trafficking of the Middle East respiratory syndrome coronavirus (MERS-CoV) M
protein. Subcellular localization analyses revealed that the MERS-CoV M protein
is retained intracellularly in the
Url:
DOI: 10.1074/jbc.RA119.008964
PubMed: 31399512
PubMed Central: 6768645
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000D84
- to stream Pmc, to step Curation: 000D84
- to stream Pmc, to step Checkpoint: 000159
- to stream PubMed, to step Corpus: 000456
- to stream PubMed, to step Curation: 000456
- to stream PubMed, to step Checkpoint: 000358
- to stream Ncbi, to step Merge: 002303
- to stream Ncbi, to step Curation: 002303
- to stream Ncbi, to step Checkpoint: 002303
- to stream Hal, to step Corpus: 000021
- to stream Hal, to step Curation: 000021
- to stream Hal, to step Checkpoint: 000002
- to stream Main, to step Merge: 000356
- to stream Main, to step Curation: 000353
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The C-terminal domain of the MERS coronavirus M protein contains a
<italic>trans</italic>-Golgi network localization signal</title><author><name sortKey="Perrier, Anabelle" sort="Perrier, Anabelle" uniqKey="Perrier A" first="Anabelle" last="Perrier">Anabelle Perrier</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Bonnin, Ariane" sort="Bonnin, Ariane" uniqKey="Bonnin A" first="Ariane" last="Bonnin">Ariane Bonnin</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Desmarets, Lowiese" sort="Desmarets, Lowiese" uniqKey="Desmarets L" first="Lowiese" last="Desmarets">Lowiese Desmarets</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Danneels, Adeline" sort="Danneels, Adeline" uniqKey="Danneels A" first="Adeline" last="Danneels">Adeline Danneels</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Goffard, Anne" sort="Goffard, Anne" uniqKey="Goffard A" first="Anne" last="Goffard">Anne Goffard</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Rouille, Yves" sort="Rouille, Yves" uniqKey="Rouille Y" first="Yves" last="Rouillé">Yves Rouillé</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Dubuisson, Jean" sort="Dubuisson, Jean" uniqKey="Dubuisson J" first="Jean" last="Dubuisson">Jean Dubuisson</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Belouzard, Sandrine" sort="Belouzard, Sandrine" uniqKey="Belouzard S" first="Sandrine" last="Belouzard">Sandrine Belouzard</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31399512</idno><idno type="pmc">6768645</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768645</idno><idno type="RBID">PMC:6768645</idno><idno type="doi">10.1074/jbc.RA119.008964</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000D84</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D84</idno><idno type="wicri:Area/Pmc/Curation">000D84</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D84</idno><idno type="wicri:Area/Pmc/Checkpoint">000159</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000159</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:31399512</idno><idno type="wicri:Area/PubMed/Corpus">000456</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000456</idno><idno type="wicri:Area/PubMed/Curation">000456</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000456</idno><idno type="wicri:Area/PubMed/Checkpoint">000358</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000358</idno><idno type="wicri:Area/Ncbi/Merge">002303</idno><idno type="wicri:Area/Ncbi/Curation">002303</idno><idno type="wicri:Area/Ncbi/Checkpoint">002303</idno><idno type="wicri:doubleKey">0021-9258:2019:Perrier A:the:c:terminal</idno><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-02323043</idno><idno type="url">https://hal.archives-ouvertes.fr/hal-02323043</idno><idno type="wicri:Area/Hal/Corpus">000021</idno><idno type="wicri:Area/Hal/Curation">000021</idno><idno type="wicri:Area/Hal/Checkpoint">000002</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000002</idno><idno type="wicri:doubleKey">0021-9258:2019:Perrier A:the:c:terminal</idno><idno type="wicri:Area/Main/Merge">000356</idno><idno type="wicri:Area/Main/Curation">000353</idno><idno type="wicri:Area/Main/Exploration">000353</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The C-terminal domain of the MERS coronavirus M protein contains a
<italic>trans</italic>-Golgi network localization signal</title><author><name sortKey="Perrier, Anabelle" sort="Perrier, Anabelle" uniqKey="Perrier A" first="Anabelle" last="Perrier">Anabelle Perrier</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Bonnin, Ariane" sort="Bonnin, Ariane" uniqKey="Bonnin A" first="Ariane" last="Bonnin">Ariane Bonnin</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Desmarets, Lowiese" sort="Desmarets, Lowiese" uniqKey="Desmarets L" first="Lowiese" last="Desmarets">Lowiese Desmarets</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Danneels, Adeline" sort="Danneels, Adeline" uniqKey="Danneels A" first="Adeline" last="Danneels">Adeline Danneels</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Goffard, Anne" sort="Goffard, Anne" uniqKey="Goffard A" first="Anne" last="Goffard">Anne Goffard</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Rouille, Yves" sort="Rouille, Yves" uniqKey="Rouille Y" first="Yves" last="Rouillé">Yves Rouillé</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Dubuisson, Jean" sort="Dubuisson, Jean" uniqKey="Dubuisson J" first="Jean" last="Dubuisson">Jean Dubuisson</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Belouzard, Sandrine" sort="Belouzard, Sandrine" uniqKey="Belouzard S" first="Sandrine" last="Belouzard">Sandrine Belouzard</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></analytic><series><title level="j">The Journal of Biological Chemistry</title><idno type="ISSN">0021-9258</idno><idno type="eISSN">1083-351X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Middle East respiratory syndrome</term><term>Viral protein</term><term>coronavirus</term><term>endoplasmic reticulum</term><term>intracellular trafficking</term><term>plasma membrane</term><term>protein motif</term><term>protein sorting</term><term>trans- Golgi network localization</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Coronavirus M proteins represent the major protein component of the viral
envelope. They play an essential role during viral assembly by interacting with
all of the other structural proteins. Coronaviruses bud into the endoplasmic
reticulum (ER)–Golgi intermediate compartment (ERGIC), but the mechanisms
by which M proteins are transported from their site of synthesis, the ER, to the
budding site remain poorly understood. Here, we investigated the intracellular
trafficking of the Middle East respiratory syndrome coronavirus (MERS-CoV) M
protein. Subcellular localization analyses revealed that the MERS-CoV M protein
is retained intracellularly in the <italic>trans</italic>-Golgi network (TGN),
and we identified two motifs in the distal part of the C-terminal domain as
being important for this specific localization. We identified the first motif as
a functional diacidic DxE ER export signal, because substituting Asp-211 and
Glu-213 with alanine induced retention of the MERS-CoV M in the ER. The second
motif, <sup>199</sup>KxGxYR<sup>204</sup>, was responsible for retaining the M
protein in the TGN. Substitution of this motif resulted in MERS-CoV M leakage
toward the plasma membrane. We further confirmed the role of
<sup>199</sup>KxGxYR<sup>204</sup> as a TGN retention signal by using
chimeras between MERS-CoV M and the M protein of infectious bronchitis virus
(IBV). Our results indicated that the C-terminal domains of both proteins
determine their specific localization, namely TGN and
ERGIC/<italic>cis</italic>-Golgi for MERS-M and IBV-M, respectively. Our
findings indicate that MERS-CoV M protein localizes to the TGN because of the
combined presence of an ER export signal and a TGN retention motif.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Masters, P X0a S" uniqKey="Masters P">P.
S. Masters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author><author><name sortKey="Netland, J" uniqKey="Netland J">J. Netland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, V X0a M" uniqKey="Corman V">V.
M. Corman</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D. Muth</name></author><author><name sortKey="Niemeyer, D" uniqKey="Niemeyer D">D. Niemeyer</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belouzard, S" uniqKey="Belouzard S">S. Belouzard</name></author><author><name sortKey="Millet, J X0a K" uniqKey="Millet J">J.
K. Millet</name></author><author><name sortKey="Licitra, B X0a N" uniqKey="Licitra B">B.
N. Licitra</name></author><author><name sortKey="Whittaker, G X0a R" uniqKey="Whittaker G">G.
R. Whittaker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heald Sargent, T" uniqKey="Heald Sargent T">T. Heald-Sargent</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T. Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruch, T X0a R" uniqKey="Ruch T">T.
R. Ruch</name></author><author><name sortKey="Machamer, C X0a E" uniqKey="Machamer C">C.
E. Machamer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nieto Torres, J X0a L" uniqKey="Nieto Torres J">J.
L. Nieto-Torres</name></author><author><name sortKey="Verdia Baguena, C" uniqKey="Verdia Baguena C">C. Verdiá-Báguena</name></author><author><name sortKey="Casta O Rodriguez, C" uniqKey="Casta O Rodriguez C">C. Castaño-Rodriguez</name></author><author><name sortKey="Aguilella, V X0a M" uniqKey="Aguilella V">V.
M. Aguilella</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Westerbeck, J X0a W" uniqKey="Westerbeck J">J.
W. Westerbeck</name></author><author><name sortKey="Machamer, C X0a E" uniqKey="Machamer C">C.
E. Machamer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Westerbeck, J X0a W" uniqKey="Westerbeck J">J.
W. Westerbeck</name></author><author><name sortKey="Machamer, C X0a E" uniqKey="Machamer C">C.
E. Machamer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Haan, C A X0a M" uniqKey="De Haan C">C. A.
M. de Haan</name></author><author><name sortKey="Rottier, P J X0a M" uniqKey="Rottier P">P. J.
M. Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Haan, C X0a A" uniqKey="De Haan C">C.
A. de Haan</name></author><author><name sortKey="Kuo, L" uniqKey="Kuo L">L. Kuo</name></author><author><name sortKey="Masters, P X0a S" uniqKey="Masters P">P.
S. Masters</name></author><author><name sortKey="Vennema, H" uniqKey="Vennema H">H. Vennema</name></author><author><name sortKey="Rottier, P X0a J" uniqKey="Rottier P">P.
J. Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Opstelten, D X0a J" uniqKey="Opstelten D">D.
J. Opstelten</name></author><author><name sortKey="Raamsman, M X0a J" uniqKey="Raamsman M">M.
J. Raamsman</name></author><author><name sortKey="Wolfs, K" uniqKey="Wolfs K">K. Wolfs</name></author><author><name sortKey="Horzinek, M X0a C" uniqKey="Horzinek M">M.
C. Horzinek</name></author><author><name sortKey="Rottier, P X0a J" uniqKey="Rottier P">P.
J. Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Haan, C X0a A" uniqKey="De Haan C">C.
A. de Haan</name></author><author><name sortKey="Smeets, M" uniqKey="Smeets M">M. Smeets</name></author><author><name sortKey="Vernooij, F" uniqKey="Vernooij F">F. Vernooij</name></author><author><name sortKey="Vennema, H" uniqKey="Vennema H">H. Vennema</name></author><author><name sortKey="Rottier, P X0a J" uniqKey="Rottier P">P.
J. Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arndt, A X0a L" uniqKey="Arndt A">A.
L. Arndt</name></author><author><name sortKey="Larson, B J" uniqKey="Larson B">B. J. Larson</name></author><author><name sortKey="Hogue, B X0a G" uniqKey="Hogue B">B.
G. Hogue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tseng, Y T" uniqKey="Tseng Y">Y.-T. Tseng</name></author><author><name sortKey="Wang, S M" uniqKey="Wang S">S.-M. Wang</name></author><author><name sortKey="Huang, K J" uniqKey="Huang K">K.-J. Huang</name></author><author><name sortKey="Lee, A X0a I R" uniqKey="Lee A">A.
I.-R. Lee</name></author><author><name sortKey="Chiang, C C" uniqKey="Chiang C">C.-C. Chiang</name></author><author><name sortKey="Wang, C T" uniqKey="Wang C">C.-T. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Haan, C A X0a M" uniqKey="De Haan C">C. A.
M. de Haan</name></author><author><name sortKey="Vennema, H" uniqKey="Vennema H">H. Vennema</name></author><author><name sortKey="Rottier, P J X0a M" uniqKey="Rottier P">P. J.
M. Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baudoux, P" uniqKey="Baudoux P">P. Baudoux</name></author><author><name sortKey="Carrat, C" uniqKey="Carrat C">C. Carrat</name></author><author><name sortKey="Besnardeau, L" uniqKey="Besnardeau L">L. Besnardeau</name></author><author><name sortKey="Charley, B" uniqKey="Charley B">B. Charley</name></author><author><name sortKey="Laude, H" uniqKey="Laude H">H. Laude</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vennema, H" uniqKey="Vennema H">H. Vennema</name></author><author><name sortKey="Godeke, G X0a J" uniqKey="Godeke G">G.
J. Godeke</name></author><author><name sortKey="Rossen, J X0a W" uniqKey="Rossen J">J.
W. Rossen</name></author><author><name sortKey="Voorhout, W X0a F" uniqKey="Voorhout W">W.
F. Voorhout</name></author><author><name sortKey="Horzinek, M X0a C" uniqKey="Horzinek M">M.
C. Horzinek</name></author><author><name sortKey="Opstelten, D X0a J" uniqKey="Opstelten D">D.
J. Opstelten</name></author><author><name sortKey="Rottier, P X0a J" uniqKey="Rottier P">P.
J. Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, K X0a P" uniqKey="Lim K">K.
P. Lim</name></author><author><name sortKey="Liu, D X" uniqKey="Liu D">D. X. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siu, Y X0a L" uniqKey="Siu Y">Y.
L. Siu</name></author><author><name sortKey="Teoh, K T" uniqKey="Teoh K">K. T. Teoh</name></author><author><name sortKey="Lo, J" uniqKey="Lo J">J. Lo</name></author><author><name sortKey="Chan, C X0a M" uniqKey="Chan C">C.
M. Chan</name></author><author><name sortKey="Kien, F" uniqKey="Kien F">F. Kien</name></author><author><name sortKey="Escriou, N" uniqKey="Escriou N">N. Escriou</name></author><author><name sortKey="Tsao, S X0a W" uniqKey="Tsao S">S.
W. Tsao</name></author><author><name sortKey="Nicholls, J X0a M" uniqKey="Nicholls J">J.
M. Nicholls</name></author><author><name sortKey="Altmeyer, R" uniqKey="Altmeyer R">R. Altmeyer</name></author><author><name sortKey="Peiris, J S X0a M" uniqKey="Peiris J">J. S.
M. Peiris</name></author><author><name sortKey="Bruzzone, R" uniqKey="Bruzzone R">R. Bruzzone</name></author><author><name sortKey="Nal, B" uniqKey="Nal B">B. Nal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klumperman, J" uniqKey="Klumperman J">J. Klumperman</name></author><author><name sortKey="Locker, J X0a K" uniqKey="Locker J">J.
K. Locker</name></author><author><name sortKey="Meijer, A" uniqKey="Meijer A">A. Meijer</name></author><author><name sortKey="Horzinek, M X0a C" uniqKey="Horzinek M">M.
C. Horzinek</name></author><author><name sortKey="Geuze, H X0a J" uniqKey="Geuze H">H.
J. Geuze</name></author><author><name sortKey="Rottier, P X0a J" uniqKey="Rottier P">P.
J. Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salanueva, I X0a J" uniqKey="Salanueva I">I.
J. Salanueva</name></author><author><name sortKey="Carrascosa, J X0a L" uniqKey="Carrascosa J">J.
L. Carrascosa</name></author><author><name sortKey="Risco, C" uniqKey="Risco C">C. Risco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Machamer, C X0a E" uniqKey="Machamer C">C.
E. Machamer</name></author><author><name sortKey="Mentone, S A" uniqKey="Mentone S">S. A. Mentone</name></author><author><name sortKey="Rose, J X0a K" uniqKey="Rose J">J.
K. Rose</name></author><author><name sortKey="Farquhar, M X0a G" uniqKey="Farquhar M">M.
G. Farquhar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Locker, J X0a K" uniqKey="Locker J">J.
K. Locker</name></author><author><name sortKey="Griffiths, G" uniqKey="Griffiths G">G. Griffiths</name></author><author><name sortKey="Horzinek, M X0a C" uniqKey="Horzinek M">M.
C. Horzinek</name></author><author><name sortKey="Rottier, P X0a J" uniqKey="Rottier P">P.
J. Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Machamer, C X0a E" uniqKey="Machamer C">C.
E. Machamer</name></author><author><name sortKey="Grim, M G" uniqKey="Grim M">M. G. Grim</name></author><author><name sortKey="Esquela, A" uniqKey="Esquela A">A. Esquela</name></author><author><name sortKey="Chung, S X0a W" uniqKey="Chung S">S.
W. Chung</name></author><author><name sortKey="Rolls, M" uniqKey="Rolls M">M. Rolls</name></author><author><name sortKey="Ryan, K" uniqKey="Ryan K">K. Ryan</name></author><author><name sortKey="Swift, A X0a M" uniqKey="Swift A">A.
M. Swift</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Machamer, C X0a E" uniqKey="Machamer C">C.
E. Machamer</name></author><author><name sortKey="Rose, J X0a K" uniqKey="Rose J">J.
K. Rose</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Locker, J X0a K" uniqKey="Locker J">J.
K. Locker</name></author><author><name sortKey="Klumperman, J" uniqKey="Klumperman J">J. Klumperman</name></author><author><name sortKey="Oorschot, V" uniqKey="Oorschot V">V. Oorschot</name></author><author><name sortKey="Horzinek, M X0a C" uniqKey="Horzinek M">M.
C. Horzinek</name></author><author><name sortKey="Geuze, H X0a J" uniqKey="Geuze H">H.
J. Geuze</name></author><author><name sortKey="Rottier, P X0a J" uniqKey="Rottier P">P.
J. Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Waguri, S" uniqKey="Waguri S">S. Waguri</name></author><author><name sortKey="Dewitte, F" uniqKey="Dewitte F">F. Dewitte</name></author><author><name sortKey="Le Borgne, R" uniqKey="Le Borgne R">R. Le Borgne</name></author><author><name sortKey="Rouille, Y" uniqKey="Rouille Y">Y. Rouillé</name></author><author><name sortKey="Uchiyama, Y" uniqKey="Uchiyama Y">Y. Uchiyama</name></author><author><name sortKey="Dubremetz, J F" uniqKey="Dubremetz J">J.-F. Dubremetz</name></author><author><name sortKey="Hoflack, B" uniqKey="Hoflack B">B. Hoflack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunn, K X0a W" uniqKey="Dunn K">K.
W. Dunn</name></author><author><name sortKey="Kamocka, M M" uniqKey="Kamocka M">M. M. Kamocka</name></author><author><name sortKey="Mcdonald, J X0a H" uniqKey="Mcdonald J">J.
H. McDonald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Venditti, R" uniqKey="Venditti R">R. Venditti</name></author><author><name sortKey="Wilson, C" uniqKey="Wilson C">C. Wilson</name></author><author><name sortKey="De Matteis, M X0a A" uniqKey="De Matteis M">M.
A. De Matteis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geva, Y" uniqKey="Geva Y">Y. Geva</name></author><author><name sortKey="Schuldiner, M" uniqKey="Schuldiner M">M. Schuldiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Votsmeier, C" uniqKey="Votsmeier C">C. Votsmeier</name></author><author><name sortKey="Gallwitz, D" uniqKey="Gallwitz D">D. Gallwitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Geng, H" uniqKey="Geng H">H. Geng</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y. Deng</name></author><author><name sortKey="Huang, B" uniqKey="Huang B">B. Huang</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y. Guo</name></author><author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z. Zhao</name></author><author><name sortKey="Tan, W" uniqKey="Tan W">W. Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bos, K" uniqKey="Bos K">K. Bos</name></author><author><name sortKey="Wraight, C" uniqKey="Wraight C">C. Wraight</name></author><author><name sortKey="Stanley, K X0a K" uniqKey="Stanley K">K.
K. Stanley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ponnambalam, S" uniqKey="Ponnambalam S">S. Ponnambalam</name></author><author><name sortKey="Rabouille, C" uniqKey="Rabouille C">C. Rabouille</name></author><author><name sortKey="Luzio, J X0a P" uniqKey="Luzio J">J.
P. Luzio</name></author><author><name sortKey="Nilsson, T" uniqKey="Nilsson T">T. Nilsson</name></author><author><name sortKey="Warren, G" uniqKey="Warren G">G. Warren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Armstrong, J" uniqKey="Armstrong J">J. Armstrong</name></author><author><name sortKey="Patel, S" uniqKey="Patel S">S. Patel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nal, B" uniqKey="Nal B">B. Nal</name></author><author><name sortKey="Chan, C" uniqKey="Chan C">C. Chan</name></author><author><name sortKey="Kien, F" uniqKey="Kien F">F. Kien</name></author><author><name sortKey="Siu, L" uniqKey="Siu L">L. Siu</name></author><author><name sortKey="Tse, J" uniqKey="Tse J">J. Tse</name></author><author><name sortKey="Chu, K" uniqKey="Chu K">K. Chu</name></author><author><name sortKey="Kam, J" uniqKey="Kam J">J. Kam</name></author><author><name sortKey="Staropoli, I" uniqKey="Staropoli I">I. Staropoli</name></author><author><name sortKey="Crescenzo Chaigne, B" uniqKey="Crescenzo Chaigne B">B. Crescenzo-Chaigne</name></author><author><name sortKey="Escriou, N" uniqKey="Escriou N">N. Escriou</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S. van der Werf</name></author><author><name sortKey="Yuen, K X0a Y" uniqKey="Yuen K">K.
Y. Yuen</name></author><author><name sortKey="Altmeyer, R" uniqKey="Altmeyer R">R. Altmeyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcbride, C X0a E" uniqKey="Mcbride C">C.
E. McBride</name></author><author><name sortKey="Machamer, C X0a E" uniqKey="Machamer C">C.
E. Machamer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Locker, J X0a K" uniqKey="Locker J">J.
K. Locker</name></author><author><name sortKey="Opstelten, D X0a J" uniqKey="Opstelten D">D.
J. Opstelten</name></author><author><name sortKey="Ericsson, M" uniqKey="Ericsson M">M. Ericsson</name></author><author><name sortKey="Horzinek, M X0a C" uniqKey="Horzinek M">M.
C. Horzinek</name></author><author><name sortKey="Rottier, P X0a J" uniqKey="Rottier P">P.
J. Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heffernan, L X0a F" uniqKey="Heffernan L">L.
F. Heffernan</name></author><author><name sortKey="Simpson, J X0a C" uniqKey="Simpson J">J.
C. Simpson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Puthenveedu, M X0a A" uniqKey="Puthenveedu M">M.
A. Puthenveedu</name></author><author><name sortKey="Linstedt, A X0a D" uniqKey="Linstedt A">A.
D. Linstedt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tu, L" uniqKey="Tu L">L. Tu</name></author><author><name sortKey="Banfield, D X0a K" uniqKey="Banfield D">D.
K. Banfield</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement></list><tree><country name="France"><region name="Hauts-de-France"><name sortKey="Perrier, Anabelle" sort="Perrier, Anabelle" uniqKey="Perrier A" first="Anabelle" last="Perrier">Anabelle Perrier</name></region><name sortKey="Belouzard, Sandrine" sort="Belouzard, Sandrine" uniqKey="Belouzard S" first="Sandrine" last="Belouzard">Sandrine Belouzard</name><name sortKey="Bonnin, Ariane" sort="Bonnin, Ariane" uniqKey="Bonnin A" first="Ariane" last="Bonnin">Ariane Bonnin</name><name sortKey="Danneels, Adeline" sort="Danneels, Adeline" uniqKey="Danneels A" first="Adeline" last="Danneels">Adeline Danneels</name><name sortKey="Desmarets, Lowiese" sort="Desmarets, Lowiese" uniqKey="Desmarets L" first="Lowiese" last="Desmarets">Lowiese Desmarets</name><name sortKey="Dubuisson, Jean" sort="Dubuisson, Jean" uniqKey="Dubuisson J" first="Jean" last="Dubuisson">Jean Dubuisson</name><name sortKey="Goffard, Anne" sort="Goffard, Anne" uniqKey="Goffard A" first="Anne" last="Goffard">Anne Goffard</name><name sortKey="Rouille, Yves" sort="Rouille, Yves" uniqKey="Rouille Y" first="Yves" last="Rouillé">Yves Rouillé</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000353 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000353 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6768645
|texte= The C-terminal domain of the MERS coronavirus M protein contains a
trans-Golgi network localization signal
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31399512" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |